Endocrine Abstracts

Introduction: Maternally-inherited diabetes with deafness (MIDD) is a rare form of monogenetic diabetes caused by a point mutation in mitochondrial DNA at a position 3243A>G. The syndrome is characterised by diabetes and sensoneural hearing impairment. Additional clinical features include short stature, cardiomyopathy, myopathy, renal disease, macular dystrophy, and gastrointestinal disease. The majority of patients usually require insulin therapy within 2 years and metfor...

Introduction: Topical wound oxygen therapy (TWO2) is therapeutic modality that delivers humidified pressurised O2 directly to the specific body part to achieve tissue penetration and increased O2 levels to the open ischaemia wound. O2 is vital in the synthesis of collagen, enhancement of fibroblasts, angiogenesis, leukocyte function, energy metabolism, and the inhibition of mycrobial growth. TWO2 therapy has showed effecti...